Development and therapeutic applications of nitric oxide-releasing materials
نویسندگان
چکیده
The role of nitric oxide (NO) in erectile physiology is well documented. NO activates relaxation of corporal cavernosal smooth muscle tissue resulting in increased blood flow into the penis resulting in an erection. At present, pharmacologic treatments for erectile dysfunction, such as the phosphodiesterase-5 inhibitors, potentiate the erectile response generated by NO. However, a new class of treatments at a preclinical stage may allow localized delivery of NO to the penis via cutaneous application. These treatments may be of particular value to patients with a neurogenic component to their erectile dysfunction, and may act synergistically with phosphodiesterase-5 inhibitors to increase their efficacy.
منابع مشابه
Nitric oxide: a brief overview of chemical and physical properties relevant to therapeutic applications
Nitric oxide (nitrogen monoxide, •NO) has been intensively studied by chemists and physicists for over 200 years and thus there is an extensive database of information that determines its biological actions. This is a very brief overview of the chemical and physical properties of •NO that are most relevant to Biology in general and to the development of •NO releasing materials in particular.
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